Regarding investigational diseases and conditions
Individual clinicians and the hyperbaric medical community are investigating the efficacy of hyperbaric oxygen
therapy (HBOT) treatment for a number of diseases and conditions. In every case the weight of scientific evidence is
currently insufficient for HBOT to be approved as a standard treatment.
The level of research activity for investigational diseases and conditions varies widely. In a number of cases there
are no clinical trials under way. This in itself should be telling for patients and caregivers investigating the
effectiveness of HBOT for off-label treatment. If there is no basis on which a clinician can form a hypothesis
about how hyperbaric oxygen might improve a medical condition, there is a good chance that it cannot.
The size, type, and quality of the studies currently under way all vary. The most pursuasive research is controlled,
double-blinded, enrolls a substantial number of patients, and is conducted at multiple medical centers.
Before being fully accepted as valid the study must be replicated by other researchers in a separate clinical trial.
None of the research into these conditions comes close to meeting these requirements.
Treatment of all these conditions with hyperbaric oxygen is considered “off-label”. Providers may not
legally advertise a specific medical benefit as resulting from treating them with hyperbaric oxygen therapy.
We create individual condition pages for investigational diseases and conditions when:
- there is sufficient clinical or public interest in treatment of the condition with HBOT,
- multiple relevant studies have been published, and
- internet resources will provide sufficient supporting references.
Conditions not meeting those criteria are listed at right.